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Abstract:

Introduction: renal arteriovenous malformation (AVM) is a pathological communication between renal arteries and veins, both acquired and congenital. Congenital AVMs of kidneys, on average, remain asymptomatic for up to 30-40 years, occurring mainly in women, may manifest with hematuria and pain. Nephrectomy is known to be historical method of treating AVM of the kidney, however, with the development of angiographic instrumentation, endovascular methods of treatment began to be introduced into practice more often.

Case report: a 30-year-old female patient with ongoing recurrent bleeding from the urogenital tract. Performed preoperative examination: laboratory tests, cystoscopy, ultrasound, multispiral computed tomography. Patient underwent angiography followed by embolization of kidney AVM with Squid.

Results: intraoperatively, it was noted that AVM embolization is partial. During the first day of the observation period, the presence of postembolization syndrome in the form of hyperthermia, pain and dysuric syndromes, a phenomenon of systemic reaction according to laboratory tests were noted. After 1,5 months, patient was hospitalized for second stage of embolizaion, but during angiography it appeared, that AVM is totally embolized.

Conclusions: renal artery embolization in patients with renal arteriovenous malformations is a minimally invasive, effective method of treatment.

1. The process of selective embolization is controlled and can be used as an independent method of treatment.

2. Due to selective catheterization of arteries and the infusion of agent directly into the affected area, segmental infarction occurs, as a result of which there is minimal destruction of the healthy part of the kidney parenchyma, the function of the kidney will not suffer.

 

References

1.     Kenny DPN, Egizi T, Camp R. Cirsoid renal arteriovenous malformation. Applied Radiology. 2016; 45: 35-37.

2.     Mukendi AM, Rauf A, Doherty S, et al. Renal arteriovenous malformation: An unusual pathology. SA Journal of Radiolog. 2019: 23(1).

3.     Rosen RJ, Ryles TS: Arterial venous malformations. In Vascular disease. Surgical and Interventional Therapy Volume 2. Edited by: Strandness DE, Van Breda A. New York, Churchill Livingstone; 1994:1121-37.

4.     Neeraj V, Cinosh M, Kim JM, et al. Massive hematuria due to congenital renal arteriovenous malformation successfully treated by renal artery embolization. J Assoc Phys India. 2018; 66: 78-80.

5.     Sorokin NI. Superselective renal artery occlusion. Diss. doct. med. sciences. M., 2015; 346 [In Russ].

 

Abstract:

Results of successful surgical treatment of a patient with an extremely rare disease - Parkes-Weber- Rubashov syndrome, manifestating by arteriovenous malformations of the lower limb and spinal cord are presented. Endovascular embolization of arteriovenous malformation of the lower limb was treated with use of three Flipper coils due to the severity of the clinical symptoms. A conclusion about the effectiveness of this method of treatment is presented. 

 

References

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2.     Boon L.M., Mulliken J.B. Assignment of a locus for dominantly inherited venous malformations to chromosome 9p. Hum. Mol. Genet. 1994; 3: 1583-1587.

3.     Brouillard P, Vikkula M. Genetic causes of vascular malformations. Hum. Mol. Genet. 2007; 16: R140-R149.

4.     Volz K.R., Kanner C.D., Evans J. Klippel-Tmnaunay Syndrome: Need for Careful Clinical Classification. J. Ultrasound Med. 2016; 10: 7863/ultra.15.08007.

5.     Namba K. and Nemoto S. Parkes Weber Syndrome and Spinal Arteriovenous Malformations. AJNR Am. J. Neuroradiol. 2013; 34: E110-E112.

6.     Djindjian M., Djindjian R. Spinal cord arteriovenous malformations and the Klippel-Trenaunay-Weber syndrome. Surg Neurol. 1977; 8:229-37.

7.     Greene A.K., Kieran M., Burrows PE. Wilms Tumor Screening Is Unnecessary in Klippel-Trenaunay Syndrome. Pediatrics. 2004; 113: e326 - e329.

8.     Fernandez-Pineda I., Lopez-Gutierrez J.C. Parkes-Weber syndrome associated with a congenital short femur of the affected limb. Ann Vasc Surg. 2009; 23(2): 257.e1-2.

9.     Revencu N., Boon L.M., Mulliken J.B. Parkes Weber syndrome, vein of Galen aneurysmal malformation, and other fast-flow vascular anomalies are caused by RASA1 mutations. Hum Mutat. 2008; 29(7): 959-65.

10.   Revencu N., Boon L.M. Parkes Weber syndrome, vein of Galen aneurysmal malformation, and other fast-flow vascular anomalies are caused by RASA1 mutations. Hum Mutat. 2008; 29:959-65.

11.   Thiex R., Mulliken J.B. A novel association between RASA1 mutations and spinal arteriovenous anomalies. AJNR Am J Neuroradiol. 2010; 31:775-79.

12.   Sato T.N., Tozawa Y Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature. 1995; 376: 70-74.

13.   Lelievre E., Bourbon PM. Deficiency in the p110alpha subunit of PI3K results in diminished Tie2 expression and Tie2(-/-)-like vascular defects in mice. Blood. 2005; 105: 3935-3938.

14.   Boon L.M., Mulliken J.B. RASA1: Variable phenotype with capillary and arteriovenous malformations. Curr Opin Genet Dev. 2005; 15(3): 265-269.

15.   Revencu N. Parkes Weber syndrome, vein of Galen aneurysmal malformation, and other fast-flow vascular anomalies are caused by RASA1 mutations. Hum Mutat. 2008; 29(7):959-965.

16.   Burrows PE., Gonzalez-Garay M.L., Rasmussen J.C. Lymphatic abnormalities are associated with RASA1 gene mutations in mouse and man. PNAS. 2013; 110: 8621-8626.

17.   Konyushevskaya A.A., Yaroshenko S.Ya. Klinicheskiy sluchay redkoy nasledstvennoy patologii - sindrom Klippelya-Trenone-Vebera-Rubashova v praktike vracha-pediatra [Rare hereditary pathology in practice of pediatrics - Klippel-Trenone-Weber-Rubashov syndrome (case report)]. Zdorov'ye rebenka. 2014; 2(53): 117 - 122 [In Russ].

18.   Behr G.G. CM-AVM syndrome in a neonate: Case report and treatment with a novel flow reduction strategy. Vasc Cell. 2012; 4(1): 19.

19.   Wijn R.S. Phenotypic variability in a family with capillary malformations caused by a mutation in the RASA1 gene. Eur J Med Genet. 2012; 55(3):191-195.  

 

 

Abstract:

This case report is about endovascular treatment of pulmonary arteriovenous malformations accompanied by severe arterial hypoxemia in the newborn. The peculiarity of this case is the extreme rarity of manifestation and successful treatment of the pathology in infancy The second feature was the use of vascular occlude devices. Currently due to the sporadic clinical observations in newborn, we consider to appropriate description of this case, focusing on the technical aspects of the intervention. 

 

References

1.     Khurshid I., Downie G. Pulmonary arteriovenous malformation. Postgrad Med J 2002; 78:191-7.

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3.     Churton T., Multiple aneurysms of pulmonary artery. BMJ. 1897; 1: 1223.

4.     Mitchell R., Austin E. Pulmonary arteriovenous malformation in the neonate. J. Pediatr. Surg. 1993; 28: 1536-1538.

5.     Porstmann W. Therapeutic embolization of arteriovenous pulmonary fistula by catheter technique. Current concepts in pediatric radiology. Springer. 1977; 23-31.

6.     Pollak J.S., Saluja S., Thabet A. et al. Clinical and Anatomic Outcomes after Embolotherapy of Pulmonary Arteriovenous Malformations. J. Vasc. Interv. Radiol. 2006; 17: 35-45.

7.     Cirstoveanu C., Balomir A., Bizubac M., Costinean S. Pulmonary arteriovenous malformation - a rare cause of hypoxemia. Practic. Med. 2012; 7: 28.

8.     Koppen S., Korver C., Dalinghaus M., Westermann C. Neonatal pulmonary arteriovenous malformation in hereditary haemorrhagic telangiectasia. Arch. Dis. Child. Fetal Neonatal Ed. 2002; 87: 226-227.

9.     Guidone P., Burrows P., Blickman J. Pediatric case of the day. Congenital pulmonary arteriovenous malformation. Am. J. Roentgenol. 1999; 173: 818-819.

10.   Trivedi K., Sreeram N. Neonatal pulmonary arteriovenous malformation. Arch. Dis. Child. 1996; 74: 80.

11.   Ravasse P., Maragnes P., Petit T., et al. Total pneumonectomy as a salvage procedure for pulmonary arteriovenous malformation in a newborn: report of one case. J. Pediatr. Surg. 2003; 38: 254-255.

12.   Trerotola S., Pyyeritz R . PAVM Embolization: An Update. AJR. 2010; 195: 837-845

13.   Swanson K., Prakash U., Stanson A. Pulmonary arteriovenous fistulas: Mayo Clinic experience. Mayo Clinic Proc. 1999; 74: 671-680.

14.   Shapiro J., Paul C. Stillwell - Diffused Pulmonary arteriovenous malformation (Angiodysplasia) with unusual histologic features: Case report and review of the literature. Pediatric Pulmonology 1995; 21: 255-261.

15.   Белозеров Ю.М., Детская кардиология. М.: Медпрессинформ. 2004;167-180. Belozerov Ju. M., Detskaja kardiologija [Pediatrics cardiology]. M.: Med-pressinform. 2004;167-180 [In Russ]. 

 

 

Abstract:

Aim: was to evaluate possibilities and advantages of endovascular treatment of intracranial aneurysms (IA) and arteriovenous malformations (AVM) using three-dimensional navigation (3D-roadmapping).

Materials and methods: during 2010-2013 years 103 embolizations of IA and AVM ir 88 patients were performed in our angiography department. Embolizations of IA were managed by metallic detachable coils, embolizations of AVM - by Histoacryl : Lipiodol glue composition. 3D-roadmapping technique was applied for guidance of endovascular tools in cerebral arteries anc catheterization the IA cavity and AVM-feeding arteries during the procedure. 3D-roadmapping technique is based on creation of composite images that consist of two-dimensional fluoroscopic views superimposed on virtual three-dimensional model of the vessel.

Results: endovascular interventions with 3D-roadmapping were performed in 65(63%) cases. In 49 (75%) cases we used 3DRA data to create three-dimensional model of cerebral vessels and in 16 (25%) cases - CT-angiography data. Complex algorithm of diagnosis and endovascular treatment of IA and AVM using 3D-roadmapping was introduced.

Conclusion: our experience of the endovascular embolization of IA and AVM with 3D-roadmapping convincingly showed that usage of this technique is possible and effective. In comparison with two-dimensional navigation there was a tendency in reduction of the effective exposure dose, also there was a statistically significant decrease of amount of contrast material , and of time for superselective catheterization of AVM-feeding arteries and IA cavity. 

 

References

1.     Becske T., Jallo G.I. Chief Editor: Lutsep H.L. Subarachnoid Hemorrhage. Updated: Oct 20, 2011 Available at: http://www.emedicine.medscape.com.

2.     Krylov V.V., Prirodov A.V., Petrikov S.S. Netravmaticheskoe subarahnoidal'noe krovoizlijanie: diagnostika i lechenie [Nontraumatic subarachnoid hemorrhage: diagnosis and treatment.]. Consilium Medicum. Bolezni serdca i sosudou 2008; 1: 14-18 [In Russ].

3.     Методические Указания 2.6.1.2944-11 «Контроль эффективных доз облучения пациентов при проведении медицинских рентгенологических исследований». Metodicheskie Ukazanija 2.6.1.2944-11 «Kontrol jeffektivnyh doz obluchenija pacientov pri provedenii medicinskih rentgenologicheskih issledovanij»[«Control of effective patient dose in medical X-ray examinations»] [In Russ].

4.     JohnstonS.C., Higashida R.T., Barrow D.L., Caplan L.R., et al: Recommendations for the endovascular treatment of intracranial aneurysms. A statement for health care professionals from the Committee on Cerebrovascular Imaging of the American Heart Association Council on Cardiovascular Radio. Выходные данные?

5.     Debrun G.M., Aletich V.A., Kehrli P., et al: Selection of cerebral aneurysms for treatment using Guglielmi detachable coils: The preliminary University of Illinois at Chicago experience. Neurosurgery. 1998;43:1281-1295.

6.     Debrun G.M., Aletich V.A., Kehrli P., Misra M., Ausman J.I., Charbel F. Selection of cerebral aneurysms for treatment using Guglielmi detachable coils: the preliminary University of Illinois at Chicago experience. Neurosurgery 1998;43:1281-1295.

7.     Fernandez Zubillaga A., Guglielmi G., Vinuela F.. Duckwiler G.R. Endovascular occlusion of intracranial aneurysms with electrically detachable coils: correlation of aneurysm neck size and treatment results. AJNR Am. J. Neuroradiol. 1994;15: 815-820.

8.     Svistov D.V., Pavlov O.A., Kandyba D.V., Nikitin A.I., Savello A.V., Landik S.A., Arshinov B.V.. Znachenie vnutrisosudistogo metoda v lechenii pacientov s anevrizmaticheskoj bolezn'ju golovnogo mozga [Meaning of intravascular method in patients with aneurysmal disease brain.]. Nejrohirurgija. 2011; 1: 21-28 [In Russ].

9.     Gallas S., Januel A.C., Pasco A., Drouineau J., Gabrillargeus J., Gaston A., Cognard C., Herbreteau D. Long-term follow-up of 1036 cerebral aneurysms treated by bare coils: a multicentric cohort treated between 1988 and 2003. J. Amer. J. Neuroradiol. 2009; 30(10): 1986-1992. 

 

Abstract:

Arteriovenous malformation (AVM) of kidney - is rarely seen vascular anomaly, with clinical polymorphism (hematuria, hypertension, left ventricular hypertrophy, heart failure, abdominal pain), and difficult diagnostic algorithms and is often a cause for radical organ-resecting operations (nephrectomy).

Article describes a case report of 37 years old patient with a diagnosis of «arteriovenous malformation of left renal artery», and the clinical picture of hematuria, post-hemorrhagic anemia. Patient underwent ultrasound of kidneys and bladder (no disease found) and multi-slice computed tomography (AVM of upper pole of left kidney, sized 5,4x5,0 cm).

Patient underwent endovascular embolization of AVM with 4 coils «Flipper». Patients was discharged on the 7th day without complications after the control ultrasound and MSCT The use of selective endovascular embolization of renal AVM reduces or removes clinical manifestations, and has lower operational risks, as well as allows you to save the function of the intact portion of renal parenchyma, which don't lead to patient's disability (in comparison with to organ-resecting surgery).

 

           References

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